Does Sernova have a cure for Type 1 Diabetes?

There are many impressive companies around the world trying to solve the world’s problems and make this a better place to live. When the right group of people can find the right environment, tremendous results can happen. Today we are going to look at one of those situations – Sernova Corp. (TSXV: SVA | OTCQB: SEOVF). Sernova is a regenerative medicine therapeutics platform company developing technologies using a medical device and immune protected therapeutic cells (i.e. human donor cells, corrected human cells and stem-cell-derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-dependent diabetes, blood disorders, and other diseases treated through replacement of proteins or hormones missing or in short supply within the body.

That’s quite a mouthful so let’s try and break that down a little. Sernova is a clinical-stage company developing products for the treatment of chronic debilitating diseases. They are working on commercially viable treatments for things like diabetes, hemophilia and neurological diseases with therapeutic cells placed into its proprietary Cell Pouch System, an implanted and scalable medical device.

Sernova’s is focusing on treating chronic diseases with regenerative medicine. Regenerative medicine can be described as the branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues. It provides the potential of a functional cure vs. masking the underlying disease and long-term treatment of symptoms with prescription medicines.

To that end, what has the market excited about Sernova is their Cell Pouch System, in particular its success in treating Diabetes. Effectively this is a novel implantable and scalable medical device which forms a natural environment in the body for the housing and long-term survival and function of therapeutic cells. These therapeutic cells release necessary proteins or factors missing from the body to treat chronic diseases as an alternative to daily administration of drugs. On Jan 15, 2021, the company announced positive preliminary safety and efficacy data from the ongoing U.S. Phase I/II Cell Pouch clinical trial for Type-1 Diabetes. In fact, one patient has now been insulin free (requiring no injectable insulin) for nine months with optimal glucose control.

This news vaulted the stock from $0.75 to over $2.00. The reason for the excitement over this news is that Sernova’s proposed solution for Type-1 Diabetes represents a potential commercial opportunity of $30 billion for the company. However, there are a lot more applications for the Cell Pouch System that Sernova is concurrently working on. They have completed a pre-clinical proof-of-concept for Hemophilia with a $10 billion estimated market size and have a clinical program under development for a Thyroid program with an estimated $2.2 billion market opportunity.

This is pretty impressive stuff but it’s by no means an overnight success story. The company began trading under the name Sernova in 2006 with the first positive results from a long-term study evaluating the Cell Pouch System in a pre-clinical model of diabetes in July 2010. This has been years in the making but is finally getting close to a deliverable, and hopefully very profitable, product.

If you or anyone you know is afflicted with any of these maladies, which therapeutic would you sign up for? An existing regime of regularly administered drugs or an implant that fixes the problem at source and requires little to no maintenance. I’m pretty sure I know what I’d sign up for assuming nothing discouraging arises from clinical trials.

With that said, there is currently no revenue being generated although they are receiving grant money to support their Diabetes research. The current burn rate is a modest $1.0 – $1.5 million per quarter and they have over $30 million of cash following a $23 million financing that closed Mar 1, 2021. So funding shouldn’t be an issue for the foreseeable future. The company has roughly 257 million shares outstanding with another 50+ million warrants making the current market cap a little over $400 million. This stock is now on the radar but with plenty of potential given the markets they are trying to tap into.

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27 responses

  1. Maribel Avatar

    I would like to recieve updates about this research and how I could buy shares of It to support It. Thanks. And if there is an ongoiing programme on Spain that I could take parte of.

  2. Richard Masud Avatar
    Richard Masud

    I am a type 1 diabetic since 1972 (48 years going). I took the Pfizer vaccine and had a brief spell of my blood sugar dropping low. I had to dink 8 kerns juice and lots of sugar and still my blood sugar was dropping. Almost went to the emergency with my daughter. Back to being diabetic with hard to control blood sugars but I believe that the Pfizer covid vaccine may have done something to my immune system and this should be investigated. To reach me: [email protected]

    1. Madeleine Avatar

      I am type one diabetes and insuline dependent. Sometimes insulin doesnt take effect and doctor can’t help solve this problem. Please help

      1. yusuf yılmaz Avatar
        yusuf yılmaz

        For now, the only treatment method is insulin and you will not have any health problems if used properly.

    2. Anna Avatar

      I had Pfizer, my glucose was no different than my normal ranges. There isn’t a definite link between the vaccines and glucose due to not enough significant data reported.

      1. sandy Avatar

        I had Pfizer and my insulin antibodies tripled. NOT everyone has insulin antibodies but definitely something to think about.

        1. Johnny Avatar

          Everyone with type one diabetes will have the antibodies associated with beta cells (there are dozens of them so not every one is screened for). Someone who hasn’t got antibodies wouldn’t have type one diabetes!!

      2. sandy Avatar

        I had a very positive reaction to the BCG vaccine, if you can find it

  3. Vijay Singh sisodia Avatar
    Vijay Singh sisodia

    I am type one diabetes please let me know i want to try this therapy

  4. Sebastian Avatar

    Please forward any new info as it becomes available

  5. Paul Lynch - Australia Avatar
    Paul Lynch – Australia

    Type 1 for about 20 years, still waiting for a cure.

  6. Saba Pervez Avatar
    Saba Pervez

    Hi how do we sign up for this clinical trial for children

    1. BASS Avatar

      Please more information about how Can I join this trial?LADA condition DIAGNOSED ALMOST 1.5 ago

    2. Lilian Kioko Avatar
      Lilian Kioko

      Kindly give us a cure…it’s sooo traumatizing to our kids… please for God’s sake

  7. Shweta Avatar

    Eagerly waiting for something positive as it is very painful for kids to live with this disorder. please find a cure soon

    1. Joan Avatar

      Please find a cure soon its so traumatizing

  8. Harvendra Singh Avatar
    Harvendra Singh

    My 13 months old grandson has tested t1d, 2days ago.its very painful to a child, 3 times injections and 3 times sugar there any other remedy .

  9. Ali Avatar

    My daughter is 7 years old and has diabetes. I hope to get treatment or something that will help her. I hope so

  10. Luke Avatar

    Sounds amazing! Would be life changing for us T1 Diabetics. Would definitely want to try this!

  11. Ali Avatar

    My daughter is 7 years old and has type 1 diabetes and takes insulin doses through an insulin pen. Are there no new treatments or innovations to treat diabetic children? Please be very sad about her condition.

  12. Ronda Richards Avatar
    Ronda Richards

    I am a type 1 diabetic since age 10.I would love to be a part of youre clinical trial! I have nothing to lose!

  13. Eva Avatar

    I have 2 kids with T1D1. My first child now 21 yrs.old, diagnosed at 2 yrs., during a heat

    wave in August. My second now 12 yrs. old was diagnosed at 11 yrs. during heat wave in August also. I wonder if the heat has anything to do with it. Type 1 doesn’t run on either side of our family, there are some type 2’s.
    Please contact me for studies. Please find a cure, the physical and emotional stress that the kids and families go through is devastating. The constant minute by minute struggle,7 days a week is simply exhausting:(

  14. Chris Smith Avatar
    Chris Smith

    I’ve been type1 diabetic for 40yrs now. Only people who have this condition truly know the stress it can put you under; mentally and physically. Please let me take part in this trial. Please God give us our cure. There is a cure. Sending so much love to all the diabetics in the world. There is a cure. All things are possible.

  15. Charles Avatar

    I’ve had Type 1 Diabetes for over 30 years. It has done severe damage to my body. I think people who have had this horrible disease for decades should be chosen first for this treatment. You can’t imagine how much we have suffered.

  16. JD Avatar

    Here is the link for enrolment in this study:
    It’s at the University of Chicago.

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